Cuproptosis is a newly discovered form of regulated cell death(RCD),which is regula-ted by the accumulation of copper ions in cells,a process that is targeted to the tricarboxylic acid(TCA)cycle.Although the basic molecular mechanism has been elucidated by scholars,there are still many aspects to be studied.In contrast,ferroptosis induced by ferric ion overload is rela-tively well-studied.In this paper,the research on ferroptosis is used as a reference to compare with cuproptosis,and the cell death induced by two metal ions is reviewed thoroughly.
关键词
铁死亡/铜死亡/分子机制/疾病状态
Key words
ferroptosis/cuproptosis/molecular mechanism/state of disease
万方数据