A型流感病毒(influenza A virus,IAV)是一种呼吸道病原体,可诱导宿主发生炎症反应,促进炎症细胞聚集,释放大量趋化因子、细胞因子以及转录因子等炎症因子,引起宿主过度炎症,导致细胞死亡和组织损伤.IAV编码的多种蛋白质可通过不同的机制参与宿主炎症反应,大大增加IAV感染的发病率和死亡率.越来越多的研究表明,免疫调节策略可以在不影响宿主抵抗感染的情况下改善疾病预后.本文综述了 IAV引发炎症反应的最新进展,以便为临床治疗IAV提供新思路.
Research Progress of Cell Inflammation Induced by Influenza A Virus
Influenza A virus(IAV)is a respiratory pathogen that can induce inflammatory re-sponse in the host.It can induce host inflammatory response and promote the aggregation of in-flammatory cells.A large number of inflammatory factors such as chemokines,cytokines,and transcription factors are released,causing excessive host inflammation and eventually leading to cell death and tissue damage.Various proteins encoded by IAV can participate in host inflamma-tory response through different mechanisms,greatly increasing the morbidity and mortality caused by IAV.A growing body of research suggests that immunomodulatory strategies can im-prove disease prognosis without affecting the host's resistance to infection.In order to provide new ideas for clinical treatment of IAV infection,this paper reviews the recent progress of IAV-induced inflammatory response.
influenza A virusinflammationimmunoregulatory therapy
万方数据
维普
