Advances of Disease-Resistant Breeding on Ovine Brucellosis
Brucellosis is a worldwide zoonotic disease caused by Brucella,which not only induces gigantic economic losses to sheep industry,but also poses significant safety hazards to public health.Brucella possesses the capability of intracellular parasitism and immune evasion,and thus the current measure of vaccination has difficulty in effectively preventing and controling Brucella infection.Cultivating new breeds of sheep resistant to brucellosis is expected to cut off the transmission route of brucellosis from the animal origin.This paper briefly describes the immune evasion mechanism of Brucella dependent on virulence factors,and systematically reviews the research progress of brucellosis resistance breeding in China and abroad,including family-based selection,genetic engineering selection and marker-assisted selection.Furthermore,candidate disease resistance genes were organized according to the development stages of inflammation and immune response.Hoping to provide a theoretical foundation for studying the pathogenic mechanism of brucellosis,identifying disease resistance genes and breeding disease resistance sheep breeds.
万方数据
维普
