Advances in Regulation of Mammalian Embryonic Development by Mitochondrial Autophagy
Mitochondrial autophagy(mitophagy)is an evolutionarily conserved process that selectively identifies,isolates and degrades specific targets.When cells are under adverse conditions,mitophagy eliminates excess or damaged mitochondria to maintain cellular homeostasis and reduce stress on cellular operations.Mitophagy plays an important role in regulation of mammalian reproduction,mainly involving in various physiological processes such as oocyte maturation,senescence and early embryonic development.This paper reviewed the biological functions of mitochondrial autophagy,the regulation of mitochondrial autophagy and the mechanisms of mitochondrial autophagy in mammalian reproduction,providing a reference for further studies on the role of mitochondrial autophagy in mammalian reproductive development.
万方数据
维普
