畜牧兽医学报2024,Vol.55Issue(4) :1401-1411.DOI:10.11843/j.issn.0366-6964.2024.04.006

抗菌肽在猪精液常温保存中的应用研究进展

Advances of the Application of Antimicrobial Peptides in the Preservation of Porcine Semen at Room Temperature

黄杰 阮子豪 蔡瑞
畜牧兽医学报2024,Vol.55Issue(4) :1401-1411.DOI:10.11843/j.issn.0366-6964.2024.04.006

抗菌肽在猪精液常温保存中的应用研究进展

Advances of the Application of Antimicrobial Peptides in the Preservation of Porcine Semen at Room Temperature

黄杰 1阮子豪 1蔡瑞1
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作者信息

  • 1. 西北农林科技大学动物科技学院陕西省动物遗传育种与繁殖重点实验室,杨凌 712100
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摘要

人工授精(AI)是畜牧业加速发展的核心技术之一,精液保存为其中的一个关键环节.猪精液在保存过程中容易受到细菌污染而导致精子质量下降,随着全面禁抗时代的到来,迫切需要开发具有不同活性的抗菌替代品,以提高精液保存效果.抗菌肽(AMPs)因具有广谱抗菌活性和较低耐药性,通过细胞膜损伤和非膜损伤机制在猪精液保存过程中发挥抗菌作用,目前已成为抗生素的重要替代品.本文综述了 AMPs的抑菌机制及其在猪精液保存技术中应用的研究进展,旨在为猪精液常温保存抗菌肽产品的开发提供科学依据.

Abstract

Artificial insemination(AI)is one of the core technologies accelerating the development of animal husbandry.Semen preservation is a key part of AI.Porcine semen is susceptible to bac-terial contamination during preservation leading to a decline in sperm quality.With the advent of the era of total antibiotic ban,there is an urgent need to develop antibacterial alternatives with different activities to improve the effect of semen preservation.Antimicrobial peptides(AMPs)have become an important substitute for antibiotics due to their broad-spectrum antimicrobial ac-tivity and lower drug resistance.AMPs play an antibacterial role in the preservation of porcine semen by exerting antibacterial effects through cell membrane damage and non-membrane dam-age mechanisms.This article reviews the research progress of AMPs'antibacterial mechanisms and their application in porcine semen preservation techniques.The aim is to provide a scientific basis for the development of antimicrobial peptide products preserved in porcine semen at room temperature.

关键词

/精液保存/抗菌肽/细菌污染/抑菌机制

Key words

pig/semen preservation/antimicrobial peptides/bacterial contamination/antibacterial mechanism

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基金项目

国家重点研发计划(2021YFF1000602)

陕西省自然科学基金(2022JQ-170)

国家生猪产业技术体系建设项目(CARS-35-PIG)

出版年

2024
畜牧兽医学报
中国畜牧兽医学会

畜牧兽医学报

CSTPCDCSCD北大核心
影响因子:0.729
ISSN:0366-6964
参考文献量85
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