Research Progress in the Regulation of Intestinal Flora on Intestinal Mucosal Immunity and Inflammation in Animals
Alterations of the gut microbiota may cause dysregulated mucosal immune responses,leading to the onset of inflammatory bowel diseases(IBD)in genetically susceptible hosts.Current effective treatments for IBD in animals are restoration of normal immune homeostasis of the gut microbiota by microbiota-targeted therapies including antibiotics,prebiotics,postbiotics,and fecal microbiota trans-plantation.In this review,the basis for promoting intestinal homeostatic immune responses through microbiota-targeted therapy,as well as recent advances in host-microbe interactions during the occur-rence and development of IBD were discussed.Given that dysbacteriosis of the intestinal flora is a key feature in the establishment of chronic inflammatory events,it is hoped that in the near future the micro-biota-targeted therapies will be appropriate to design new cost-effective,physiological,animal-oriented IBD treatment strategies to be applied in a personalized manner.
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