Research Progress of Non-coding RNA in Infectious Bursal Disease Virus Infection
Infectious bursal disease(IBD)is an acute,highly contagious,and immunosuppressive avian disease caused by infectious bursal disease virus(IBDV).In recent years,with the emer-gence of IBDV novel variant strains,IBDV still threatens the poultry industry worldwide.It seems that the battle between host and IBDV will never end.Thus,it is urgent to develop a more comprehensive and effective strategy for the control of this disease.A better understanding of the mechanisms underlying virus-host interactions would be of help in the development of novel vac-cines.Noncoding RNA(ncRNAs)are an abundant class of RNAs that do not encode proteins.NcRNAs include microRNA(miRNAs),long noncoding RNA(lncRNAs),circular RNA(cir-cRNAs)and small nuclear RNA(snRNAs).Recently,many studies confirmed that noncoding RNA(ncRNAs)were widely involved in the interaction of IBDV and the host,and played a cru-cial regulatory role in IBDV infection.This review elaborated the role of miRNAs,lncRNAs,and circRNAs in IBDV infection,which will further provide theoretical guidance and new ideas for the development of novel IBDV vaccines or antiviral drugs.
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