SNP遗传力估计方法、影响因素及其在畜禽育种中的应用
The Evaluated Methods and Influencing Factors of SNP Heritability and Its Application in Farmer Animal Breeding
段益欣 1张林云 1赵永聚1
作者信息
- 1. 西南大学动物科学技术学院草食动物科学重庆市重点实验室重庆市草食动物资源保护与利用工程技术研究中心,重庆 400715
- 折叠
摘要
遗传力是衡量由遗传因素解释的表型方差的比例,在实际遗传力估计中多只考虑加性遗传效应.由于畜禽传统遗传力估计需要的系谱信息完整性和准确性较难以实现,随着基因组学的发展,以全基因组单核苷酸多态性(SNP)进行遗传力估计的方法得到广泛应用.而对SNP遗传力的准确估计有利于了解遗传变异对表型的作用程度,目前已有不少SNP遗传力估计模型被开发利用.本文主要综述了SNP遗传力的概念、常用估计方法及其影响因素,并与传统遗传力估计进行比较,探究了SNP遗传力在畜禽育种中的应用潜力.
Abstract
Heritability is a measure of the proportion of phenotypic variance explained by genetic factors.In actual heritability evaluation,only additive genetic effects are considered.With the development of genomics,genome-wide single nucleotide polymorphisms(SNPs)have been widely used to evaluate heritability because of the difficulty in achieving the integrity and accuracy of genealogy information that traditional heritability estimation relies on.However,accurate evaluation of SNP heritability is helpful in understanding the extent of genetic variation's effect on phenotype.Currently,many SNP heritability evaluation models have been developed and utilized.In this paper,the concept,common evaluation methods and influencing factors of SNP heritability are reviewed,and a comparison was made between SNP heritability and the traditional heritability estimation,in order to explore the potential application of SNP heritability in livestock breeding.
关键词
SNP遗传力/遗传力缺失/影响因素/估计模型/畜禽育种Key words
SNP heritability/loss of heritability/influencing factors/estimation model/farmer animal breeding引用本文复制引用
基金项目
国家重点研发计划(2022YFD1300200)
重庆市现代农业产业技术体系建设项目(CQMAITS202313)
重庆市科企联合体种质资源收集利用与品种试验项目(草食牲畜)()
出版年
2024
国家科技期刊平台
NSTL
万方数据