Progress on the Application of CD46 in Breeding of Livestock for Disease Resistance
Complement regulatory protein 46(CD46)is widely expressed in most mammalian cells.In addition to its various physiological functions such as complement inactivation,regulation of T cell activation and fertility,CD46 can also serve as a receptor for various bacteria and viruses.It is especially important for the attachment of bovine viral diarrhea virus(BVDV)and classical swine fever virus(CSFV).The use of gene editing technology to specifically modify CD46 has successfully produced live calve that can resist BVDV infections,proving that this gene can be used as a candidate gene for disease resistance breeding.This article mainly reviews the role of CD46 protein in livestock virus infection and its application in disease resistance breeding.
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