表观遗传学调控雌性动物初情期启动的研究进展
Advances in Epigenetic Regulation of the Onset of Puberty in Female Animals
张为 1潘志豪 1方富贵1
作者信息
- 1. 安徽农业大学动物科技学院,合肥 230036
- 折叠
摘要
雌性动物初情期是指第一次出现发情表现并排卵的时期.初情期启动机制复杂,与遗传、神经内分泌、代谢、营养和环境等因素密切相关.但动物初情期启动的具体机制仍不明确.最近的证据表明,表观遗传机制是调节动物初情期启动过程的重要协调者.本文总结了DNA甲基化、组蛋白修饰、非编码RNA、染色质重塑、基因组印记、转录因子结合和X染色体失活等表观遗传机制对初情期启动的影响,为深入研究雌性动物初情期启动的机制提供参考和依据.
Abstract
The puberty of female animals is the period when the estrus appears and ovulation occurs for the first time.The mechanism of puberty onset is complex and closely related to genetic,neuroendocrine,metabolic,nutritional,and environmental factors and so on.However,the specific mechanism of animal puberty onset is still unclear.Recent evidence suggests that epigenetic mechanisms are important coordinators in the process of animal puberty onset.The paper reviews the effects of epigenetic mechanisms such as DNA methylation,histone modification,non-coding RNA,chromatin remodeling,genome imprinting,transcription factor binding,and X chromosome inactivation on the onset of puberty,which provides a reference and basis for the further study of the mechanism of puberty onset in female animals.
关键词
初情期/表观遗传/DNA甲基化/组蛋白修饰/非编码RNAKey words
puberty/epigenetic/DNA methylation/histone modification/non-coding RNA引用本文复制引用
基金项目
国家自然科学基金(31972629)
安徽农业大学大学生创新创业训练计划(X202310364048)
出版年
2024
国家科技期刊平台
NSTL
万方数据