首页|反刍动物瘤胃微生物LuxS/AI-2群体感应研究进展

反刍动物瘤胃微生物LuxS/AI-2群体感应研究进展

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
群体感应(quorum sensing,QS)是细菌利用信号分子进行种内或种间交流的一种通讯机制,借助该通讯机制微生物群体可以实现微生物个体无法完成的生理功能或行为调节,如生物膜形成、毒素分泌和生物发光等,以增强对外界胁迫环境的适应性.近期多组学研究发现,以自体诱导物-2(autoinducer-2,AI-2)为信号分子、LuxS为调节蛋白介导的LuxS/AI-2 QS是瘤胃微生物之间交流的主要通讯机制,影响着瘤胃微生物对饲料的利用效率.本文从AI-2的化学结构和转导途径对微生物LuxS/AI-2 QS进行总结,对LuxS/AI-2 QS在反刍动物瘤胃微生物定殖和饲料消化过程中的作用进行综述,并对LuxS/AI-2 QS在饲料消化、应激调控中的潜在作用进行展望,以期为通过LuxS/AI-2 QS调控瘤胃微生物消化代谢和稳态的生产策略提供理论参考.
Research Progress on LuxS/AI-2 Quorum Sensing of Rumen Microbe in Ruminants
Quorum sensing(QS)is a communication mechanism utilized by bacteria to facilitate intra-species or inter-species communication through the signaling molecules.Through this communication mechanism,microorganisms can collectively conduct physiological functions or regulate behaviors that cannot be achieved by microbial individual.These functions include biofilm formation,toxin secretion,bioluminescence,and other adaptive responses to enhance the adaptability of microorganisms against external stress environment.Recently,multi-omics studies have revealed that LuxS/AI-2 QS,mediated by the autoinducer-2(AI-2)signaling molecule and regulated by the LuxS protein,serves as the primary communication mechanism among rumen microbe,influencing their efficiency in feed utilization.This review provides a summary of the LuxS/AI-2 QS in rumen microbe,focusing on the chemical structure of AI-2 and its transduction pathways.The roles of LuxS/AI-2 QS in rumen microbial colonization and feed digestion in ruminants were reviewed,as well as the potential roles of LuxS/AI-2 QS in feed digestion and stress regulation.This review may provide a theoretical reference for production strategy by regulating the digestive metabolism and homeostasis of rumen microbe through LuxS/AI-2 QS.

LuxS/AI-2 quorum sensingbiofilmrumen microbecommunity stabilityfeed digestion

龙唐晖、周江汇、詹彦波、张健、赵向辉、李艳娇、欧阳克蕙、邱清华

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江西农业大学动物科学技术学院/江西省动物营养重点实验室/江西省营养饲料开发工程研究中心,南昌 330045

LuxS/AI-2群体感应 生物膜 瘤胃微生物 群落稳定性 饲料消化

国家自然科学基金国家自然科学基金江西省自然科学基金江西省主要学科学术和技术带头人培养计划"领军人才"项目江西农业大学年轻科研创新团队项目

322608613216080720232BAB21505120213BCJL22043JXAUCXTD008

2024

10.11843/j.issn.0366-6964.2024.05.008

畜牧兽医学报
中国畜牧兽医学会

畜牧兽医学报

CSTPCD北大核心
影响因子：0.729
ISSN：0366-6964
年,卷(期)：2024.55(5)
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