Research Progress on the Mechanism of Intestinal Flora-Mediated Regulation of Intestinal Mucosal Immunity by Secondary Bile Acids and Their Receptors
Bile acids are cholesterol derivatives that have been shown to be remarkably effective in improving the digestion and absorption of fats in the daily diet.In the liver,cells utilize cholesterol to form primary bile acids,while under the influence of proteases secreted by intestinal flora,primary bile acids turned to secondary bile acids,which greatly expanding the molecular diversity of the intestinal environment.Currently,the most common secondary bile acid receptors are transmembrane G protein bile acid-coupled receptor-5(GPBAR1,also known as TGR5)and the nuclear receptor farnesoid X receptor(FXR),which play pleiotropic roles in the regulation of organismal health,in particular to maintain intestinal flora homeostasis and mucosal immune system homeostasis.This review discusses the relationship between bile acids and intestinal flora,the metabolism of secondary bile acids,and the different mechanisms of action of secondary bile acids and their receptors in the intestinal immune system,which may provide a theoretical basis for the prevention and control of intestinal diseases in animals as well as related research.
intestinal florasecondary bile acidsG protein bile acid-coupled receptor-5nuclear receptor farnesoid X receptormucosal immunity
国家科技期刊平台
NSTL
万方数据
