Research Progress on the Role of HIF-1α in Pathogen Infections
Hypoxia-inducible factor-1α(HIF-1α)is a central regulatory factor in cellular response to hypoxia.Stable HIF-1α has multiple functions and is involved in various biological processes,including angiogenesis,metabolic regulation,autophagy,and apoptosis.The stability of HIF-1αis regulated by multiple signals,including oxygen levels,pathogen infections,and metabolic in-termediates.In recent years,increasing evidence has shown that HIF-1α plays an important role in infectious diseases.Therefore,this article discusses and summarizes the regulatory mecha-nisms of HIF-1α stability and its role in viral,bacterial,and other pathogen infection,as well as in the development of related diseases,aiming to provide references for further study on the role of HIF-1α in defending against various pathogen infections and its potential as a target for targe-ted therapy.
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