Research Progress on the Molecular Mechanisms of Immune Escape of Japanese Encephalitis Virus
Japanese encephalitis(JE)is a mosquito-borne animal disease caused by Japanese en-cephalitis virus(JEV),although commercially vaccines are availabe,however,the vaccines has certain limitations and there is no effective drug treatment so far,and once the outbreak occurs,people's life and health as well as the public safety will be threatened,thus resulting in significant economic losses.JEV contains a large number of encoded proteins with immune escape function.The mechanism of these proteins escaping host immune function is diverse and complex,and the mechanism of which still remains unclear.At the same time,the complex immune escape mecha-nism of JEV may be the key factor hindering the immune protection effect of vaccine.Therefore,this paper mainly summarizes the mechanism of JEV escaping innate and adaptive immunity by inhibiting interferon response,regulating apoptosis,pyroptosis,autophagy and host miRNA to provide ideas and theoretical basis for the research of JEV pathogenesis and vaccine development.
Japanese encephalitis virusimmune escapeinnate immunityadaptive immunity
万方数据
维普
