Japanese encephalitis(JE)is a mosquito-borne animal disease caused by Japanese en-cephalitis virus(JEV),although commercially vaccines are availabe,however,the vaccines has certain limitations and there is no effective drug treatment so far,and once the outbreak occurs,people's life and health as well as the public safety will be threatened,thus resulting in significant economic losses.JEV contains a large number of encoded proteins with immune escape function.The mechanism of these proteins escaping host immune function is diverse and complex,and the mechanism of which still remains unclear.At the same time,the complex immune escape mecha-nism of JEV may be the key factor hindering the immune protection effect of vaccine.Therefore,this paper mainly summarizes the mechanism of JEV escaping innate and adaptive immunity by inhibiting interferon response,regulating apoptosis,pyroptosis,autophagy and host miRNA to provide ideas and theoretical basis for the research of JEV pathogenesis and vaccine development.
关键词
日本脑炎病毒/免疫逃逸/天然免疫/适应性免疫
Key words
Japanese encephalitis virus/immune escape/innate immunity/adaptive immunity
维普
万方数据