Establishment on Commonly Used Antimicrobials Epidemiological Cut-off Values of Mycoplasma synoviae
Mycoplasma synoviae(MS)is one of the most detrimental mycoplasmas in the large-scale poultry industry.Meanwhile,the development of antimicrobial resistance to MS is serious currently.In order to understand the current situation of antimicrobial resistance to MS,the re-search was conducted in reference to the method of establishing epidemiological/wildtype cut-off values(ECOFFs/COWT)in CLSI and EUCAST by collecting and summarizing MIC from differ-ent regions and sources in recent 5 years after searching relevant literature reports at home and abroad,and then the ECOFFs of various antimicrobial agents to MS were obtained through com-prehensive analysis using visual estimation,ECOFFFinder software analysis and Normalized Drug Resistance Interpretation(NRI).Subsequently,the corresponding drug resistance rates were calculated.It showed that the ECOFFs of MS to tylosin,tilmicosin,tylvalosin,doxycyc-line,oxytetracycline,chlortetracycline,tiamulin,lincomycin,florfenicol and spectinomycin were 1,0.5,0.5,2,4,2,2,2,8 and 4 μg·mL-1 respectively.In absence of sensitive breakpoint of MS in CLSI and ECUAST,the theoretical basis and scientific evidence are provided by this re-search for the rational use of drugs in clinical practice,development of antimicrobial resistance work for monitoring and reducing it,and also beneficial for the treatment and control of MS.
Mycoplasma synoviaeepidemiological cut-off valuesdrug resistanceECOFFinder softwarenormalized drug resistance interpretation(NRI)
万方数据
维普
