首页|氧化应激对母畜卵巢功能影响的研究进展

氧化应激对母畜卵巢功能影响的研究进展

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卵巢是母畜生殖系统的重要组成部分,其功能受多种因素的调控,其中氧化应激作为一种重要的细胞生物学过程,被发现对卵巢功能产生深远影响。卵巢内氧化与抗氧化物的平衡对维持卵巢功能意义重大,卵巢内活性氧(reactive oxygen species,ROS)参与卵母细胞生长、减数分裂、排卵和其他生理过程的调节,ROS堆积可导致卵巢功能紊乱,影响优势卵泡形成,对卵母细胞成熟、受精以及随后的胚胎植入和发育均有影响。本文针对氧化应激对母畜卵巢功能的影响,进一步探究了氧化应激对母畜卵母细胞、颗粒细胞、卵泡膜细胞以及黄体的影响,深入了解其机制有助于揭示卵巢生理和病理的内在联系,为相关疾病的预防和治疗提供新的思路。
Research Progress in the Effect of Oxidative Stress on Ovarian Function in Female Livestock
The ovary is an important component of the reproductive system of female livestock,and its function is regulated by many factors,among which oxidative stress,as an important cellular biological process,has been found to have a profound effect on the ovarian function.The balance between oxidation and antioxidants in the ovary plays a significant role in maintaining ovarian function.Reactive oxygen species(ROS)in the ovary participates in the regulation of oocyte growth,meiosis,ovulation,and other physiological processes.The accumulation of ROS can lead to ovarian dysfunction and affect the formation of dominant follicles.It has influence on oocyte maturation,fertilization,and subsequent embryo implantation and development.Aiming at the effects of oxidative stress on ovarian function of female animals,this paper further explored the effects of oxidative stress on oocytes,granulosa cells,follicular membrane cells and corpus luteum of female animals,and in-depth understanding of the mechanism will help reveal the internal relationship between ovarian physiology and pathology,and provide new ideas for the prevention and treatment of reproduction related diseases.

female livestockoxidative stressovaryoocytegranulosa cellcorpus luteummitochondria

孟亚轩、刘彦、王晶、陈国顺、冯涛

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北京市农林科学院畜牧兽医研究所,北京 100097

北京市农林科学院—美国俄克拉荷马州立大学动物科学联合实验室,北京 100097

甘肃农业大学动物科学技术学院,兰州 730070

母畜 氧化应激 卵巢 卵母细胞 颗粒细胞 黄体 线粒体

国家自然科学基金北京市农林科学院课题

31972575CZZJ202205

2024

畜牧兽医学报
中国畜牧兽医学会

畜牧兽医学报

CSTPCD北大核心
影响因子:0.729
ISSN:0366-6964
年,卷(期):2024.55(7)
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