首页|基于智能饲喂开展哺乳母猪采食量基因组遗传评估研究

基于智能饲喂开展哺乳母猪采食量基因组遗传评估研究

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
旨在通过分析哺乳母猪采食量性状的遗传参数及全基因组关联分析(GWAS),评估基于智能饲喂技术对哺乳期采食性状的选育效果.本研究收集2022年7月至2023年5月份分娩的922头1～4胎次大白猪的哺乳期采食量数据,分析猪只的哺乳期采食情况.利用Hiblup软件对哺乳期采食性状进行遗传参数估计,后使用Plink、GEMMA和R软件进行全基因组关联分析,筛选与采食量性状相关的SNP位点及重要候选基因,并对显著关联的SNP位点上、下游420 kb范围内注释基因进行功能富集分析.结果显示,纯种大白猪哺乳期采食性状遗传力在0.20～0.27之间,并筛选到28个SNPs位点与哺乳期采食性状显著相关.通过对相关联的SNPs位点进行注释,共筛选到15个与哺乳期采食性状相关的候选基因,这些候选基因显著富集在葡萄糖、脂肪酸、激素和辅酶等的合成代谢多个生物学过程(P＜0.05),分析认为HAMP、NDUFB8、UPK1A、CHSY1、U6、COX7A1可作为大白猪哺乳期采食性状的关键候选基因.以上研究结果为大白猪哺乳期采食性状提供重要的遗传变异位点与后续基因,为后期利用该遗传分子标记进一步改良采食量性状的选育奠定基础,也将为大白猪哺乳母猪高繁殖力和高泌乳性能品种选育提供理论支撑.
Research on Feeding Capacity Selection of Lactating Sows Based on Intelligent Precision Feeding
This study aimed to analyze the genetic parameters of feed intake traits in lactating sows and conduct a genome-wide association study(GWAS)to evaluate the impact of intelligent feeding technology on these traits during lactation.Feed intake data from 922 first to fourth parity Large White pigs,born between July 2022 and May 2023,were collected to analyze feeding conditions during lactation.The Hiblup software estimated the genetic parameters of feeding traits during lactation,while Plink,GEMMA,and R software conducted a genome-wide association study to identify significant SNP loci and candidate genes associated with feed intake traits.Functional enrichment analysis was then performed on annotated genes within the 420 kb range surrounding these SNP loci.The results indicated that the heritability of feeding traits in lactating Large White pigs ranged from 0.20 to 0.27,and 28 SNP sites were significantly correlated with these traits.Annotation of the associated SNP sites identified 15 candidate genes related to lactation feeding traits,which were significantly enriched in anabolic processes including glucose,fatty acids,hormones,and coenzymes(P＜0.05).HAMP,NDUFB8,UPK1A,CHSY1,U6,and COX7A1 were identified as key candidate genes for feeding traits in Large White pigs during lactation.The above research results provide crucial genetic variation sites and associated genes linked to feeding traits in Large White pigs during lactation,establishing a foundation for further enhancement of feed intake traits by utilizing these genetic markers in future breeding programs,and also offers theoretical support for the breeding of lactating Large White sows with enhanced fertility and lactation performance.

intelligent feedingnursing sowfeed intake breedinggenome-wide association studySNP marker

张瑞琪、厐彦芹、李再山、尚秀国、兰干球、郭金彪、赵云翔

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广西大学动物科学技术学院,南宁 530004

佛山科学技术学院生命科学与工程学院,佛山 528225

广西扬翔股份有限公司,贵港 537100

智能饲喂 哺乳母猪 采食量选育 全基因组关联分析 SNP标记

广西科技重大专项国家现代农业产业技术体系国家现代农业产业技术体系广西创新团队建设专项资金资助&&

桂科AA23073020CARS-PIG-35nycytxgxcxtd-2023-15-032022YFD1601307

2024

10.11843/j.issn.0366-6964.2024.07.010

畜牧兽医学报
中国畜牧兽医学会

畜牧兽医学报

CSTPCD北大核心
影响因子：0.729
ISSN：0366-6964
年,卷(期)：2024.55(7)
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