This study aimed to investigate the effects of glucosamine(GlcN)on the growth performance,antioxidant capacity and immune function of weaned piglets.Two hundred and fifty 21-day-old healthy Duroc×Landrance × Yorkshire weaned piglets of similar weight were selected and randomly divided into 5 treatment groups with 5 replicates in each group.The basal diet(NC group),the basal diet+chlortetracycline 75 g·kg-1(PC group),the basal diet+GlcN 1 g·kg-1(G1 group),the basal diet+GlcN 2 g·kg-1(G2 group)and the basal diet+GlcN 3 g·kg-1(G3 group)were fed respectively for 35 days.The results showed that:1)Compared with the NC group,the ADFI and ADG of day 15 to 35 and day 1 to 35 of the other four groups were increased significantly,and the diarrhea rate of day 1 to 35 in G1,G2 and G3 groups were decreased significantly(P＜0.05).2)Compared with the NC group,the serum MDA levels of the other four groups were significantly reduced,the serum CAT activity in the G1,G2 and G3 groups were significantly increased(P＜0.05);the serum IL-1β levels of the G2 group and the serum TNF-α levels of the G1 group were significantly reduced(P＜0.05)at day 14.The serum MDA levels were significantly decreased and the serum CAT activity were significantly increased in the other four groups,and the serum T-AOC in the G2 and G3 groups were significantly increased(P＜0.05);the serum IL-10 levels in the G1 group was significantly increased,and the serum IL-1β levels in the PC group and the G1 group were significantly reduced(P＜0.05)at day 35.3)Compared with the NC group,the serum A/G in the PC,G1 and G3 groups were significantly increased,and the serum AST levels in the other four groups were decreased significantly(P＜0.05)at day 35.In summary,GlcN can improve the growth performance,reduce diarrhea rate,enhance antioxidant capacity,and immune function in weaned piglets.The appropriate dosage of GlcN is 1 g·kg-1,and its effect is better than 75 mg·kg-1 chlortetracycline.
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