Progress in Research of Major Capsid Protein of Calicivirus
Calicivirus is a single-stranded positive-sense RNA and non-enveloped viruse,which has a wide host range and thus seriously threaten the health of humans and many other vertebrates.Due to the variety of virus species and epidemic strains,easy transmission and regional infection,public health diseases caused by calicivirus frequently broke out worldwide,and its incidence of infection has increased significantly in recent years.Although different genera infect different types of hosts,their main capsid proteins have similar structures.The major capsid protein of calicivirus contains critical regions of immunogenicity,which can bind to host receptors and may mediate the infection process.Moreover,amino acid-related immunogenicity and variation of re-ceptor binding sites are recognized as driving forces of viral evolution.In this paper,we reviewed the progress of research on the genomic structure,immunogenicity,receptor binding and genetic evolution of the major capsid proteins of calicivirus,with a view to providing references for sub-sequent scientific research and effective prevention and control of related diseases.
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