Genetic Manipulation of Eimeria:Platform Development,Application,and Perspective
The genus of Eimeria parasite is the most common parasite in poultry and livestock,causing severe digestive system diseases in animals such as chickens,rabbits,sheep,and cattle,which affect animal health and the economic benefits of animal farming.With the rapid develop-ment of molecular biology technologies,researchers have established genetic manipulation plat-form for Eimeria,including transient transfection,stable selection,and gene editing.These techniques have realized gene overexpression,gene knockout,and gene editing in Eimeria,greatly advancing the understanding of Eimeria's basic biology and its potential as a novel eu-karyotic vector vaccine.However,challenges still remain in this field.This article systematically reviews and summarizes the key technologies,innovative designs,technical bottlenecks,and ap-plication prospects of Eimeria's genetic manipulation platform,providing references for the es-tablishment of genetic manipulation platform for other livestock parasites and offering new in-sights for the development of new control measures against coccidiosis.
国家科技期刊平台
NSTL
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