摘要
锰作为生命活动中重要微量元素参与了多种生理过程.对于能量代谢、神经系统发育和免疫系统正常运行至关重要.与可溶性锰离子相比,纳米锰可维持锰离子在注射部位持续释放,以诱导局部的免疫应答,并增强树突状细胞(dendritic cells,DCs)对抗原的摄取,促进DCs在体内活化与成熟.本文从纳米锰作用机制、制备方法、功能表征、纳米佐剂存在的问题和解决策略等方面进行综述,重点介绍了纳米锰作为疫苗佐剂的应用,并提出存在问题及解决策略.
Abstract
Manganese is an important trace element that participates in various physiological processes,including skeletal,reproductive,energy metabolism,and normal functioning of the nervous and immune systems.Compared with soluble manganese ions,nano-manganese can maintain the continuous release of manganese ions at the injection site,induce local immune re-sponses,and enhance the cellular uptake of antigens by dendritic cells(DCs),promoting the acti-vation and maturation of DCs in the body.This article reviews the relevant issues of nano-manga-nese from the perspectives of their mechanism of action,preparation methods,functional charac-terization,problems with nano adjuvants,and solutions.The application of nano-manganese as vaccine adjuvants was emphasized and the problems and solutions of nano-manganese were pro-posed.
基金项目
河南省科技攻关计划(232102310381)
河南牧业经济学院博士科研启动资金项目(2022HNUAHEDF033)
国家重点研发计划子课题(2021YFD1301201)
国家科技期刊平台
NSTL
万方数据