Progress on the Characteristics of Virus-encoded Proteins and Pathogenic Mechanism of Henipavirus
Henipavirus(HNV)is an important new class of zoonotic pathogens,which can cause respiratory and neurological diseases through contact,oral and nasal transmission,and the mortality rate is as high as 75％.HNV belongs to the negative stranded single-stranded RNA envelope virus of the paramyxoviridae family.With the change of environment,new virus subtypes continue to emerge and the spread of the scope gradually expands,which seriously threatens global public health security,economic development and social stability.However,the pathogenic mechanism of infection is not clear,and preventive vaccines and therapeutic drugs have not been marketed,which has aroused great concern from WHO,and the research and development of vaccines and drugs has been included in the list of blueprints that require urgent research and development.This review summarizes the etiological characteristics,structure and functions of the encoded proteins,and pathogenic mechanism of HNV,so as to provide ideas for the development of drugs and vaccines for effective intervention in HNV infection.
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