Research Progress on in vitro Culture and Induced Differentiation of Non-human Primate Pluripotent Stem Cells
Stem cells have great value in disease occurrence,cell therapy,drug screening,and clinical applications.Since Shinya Yamanaka,a Japanese scientist,discovered induced pluripo-tent stem cells(iPSCs),the relevant research has become a research hotspot and up to the pres-ent.The study of mouse stem cells has opened up a path for the related research in other ani-mals,but there are significant limitations in drug screening and disease treatment.Non-human primates have higher genetic homology with humans and are highly similar to humans in physiol-ogy,pathology,reproduction,pharmacology,nerves,and other aspects.They are ideal animal models for studying human diseases and developing drugs for human.Research on non-human primates is also a necessary step for a new drugs before entering clinical trials.The study of non-human primate stem cells is becoming important in the mechanism of diseases and drug develop-ment,while avoiding ethical issues.This article reviews the related research on non-human pri-mate pluripotent stem cells including optimization of in vitro culture systems and methods of in-ducing differentiation,aiming to provide reference for further in-depth research on non-human primate stem cells.
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