In order to explore the correlation between neutralizing antibody and E2 antibody against classical swine fever virus(CSFV),289 swine sera were detected using both neutraliza-tion assay and ELISA among which neutralizing antibody titers of 15 sera were further tested by neutralization assay using different CSFV strains.The results showed that E2 antibody level a-gainst CSFV was positive correlated with neutralizing antibody titer.When the individual per-centage inhibition of E2 antibody was over 60%,the neutralizing antibody titer of more than 70%vaccinated pigs in the herd meet the protection standard.These results could help the local veteri-naries to evaluate the efficacy of CSFV vaccine better in the field and reduce the risk of CSF out-break.