The Preventive Effect of Schisandrin A on Chicken Colibacillosis and Its Impact on Immune Function
To investigate the preventive effect of schisandrin A against chicken colibacillosis,180 one-day-old chicks were divided into the following groups:control group,Escherichia coli infec-tion group,50 mg·kg-1 schisandrin A group,100 mg·kg-1 schisandrin A group,200 mg·kg-1 schisandrin A group,and antibiotic group(florfenicol).After 5 days of administration,except for the control group,all other groups were intraperitoneally inoculated with E.coli suspension.The chicks'body weight,immune organ index,spleen histopathological and ultrastructural chan-ges,blood cell count,serum inflammatory factors,antibody levels,and immunoglobulin changes were evaluated.The results demonstrated that pre-feeding schisandrin A improved the body weight of infected chicks,significantly reduced the spleen index,alleviated spleen tissue damage and cellular nuclear and mitochondrial injuries caused by E.coli infection.Furthermore,200 mg·kg-1 schisandrin A significantly reduced the white blood cell count in infected chickens,while both 100 mg·kg-1 and 200 mg·kg-1 schisandrin A groups significantly decreased the levels of TNF-α,IL-1β,IL-6,and IL-8 in the serum of infected chickens,and significantly increased the antibody levels of IgM,IgG,and NDV.In summary,schisandrin A exerted a disease-resist-ant effect against avian colibacillosis by modulating the immune response.
万方数据
维普
