Explore the"Cross-talk"between Skeletal Muscle Satellite Cells and the Niche Cells Based on Single-cell Sequencing Technology
Single-cell sequencing is a cutting-edge technology for high-throughput sequencing of genomes,transcriptomes,and epigenomes of individual cells,offering a powerful tool to charac-terize individual cells and elucidate interactions between cells,and has provided many new in-sights in tumorigenesis and stem cell biology.Mammalian skeletal muscle is a heterogeneous tis-sue dominated by myofibers,including various kinds of cells such as muscle satellite cells,fibro-adipogenic progenitors and macrophages,et al.Benefiting from the rapid development of single-cell sequencing technology,the understanding of the composition of cell populations and the in-teractions between different kinds of cells within skeletal muscle has gradually expanded.Here,the biological meanings of the interaction of muscle satellite cells with the niche cells on the growth,metabolism and regeneration of skeletal muscle has been reviewed,with the aim to pro-vide new ideas to improve the growth rate and meat quality of meat-producing animals.
skeletal musclesingle-cell sequencingmuscle satellite cellscell communication
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