首页|冠心病模式猪的研究进展

冠心病模式猪的研究进展

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冠状动脉粥样硬化性心脏病(冠心病)是一种常见的心血管疾病,严重影响全球人类健康。由于其复杂的发病机制和治疗难度,冠心病的研究一直备受关注。近年来,动物模型在心血管疾病研究中发挥着关键作用,猪的心血管系统在解剖结构和病理生理机制等方面均与人类较为相似,因此模式猪已被广泛认可为动脉粥样硬化研究中的优良模型。本文旨在通过参照人类冠心病的诊断指标与高危因素,探讨建立可用于模拟人类临床冠心病的医用模式猪的评价标准和构建方法,为冠心病发病机制与临床应用前研究提供良好的实验模型。本综述将为冠心病新型诊疗药物和检测方法的开发提供参考。
Research Progress of Coronary Heart Disease Model Pigs
Coronary heart disease(CHD)is a common cardiovascular disease that seriously affects human health worldwide.Considering its complex pathogenesis and the difficulty of treatment,the study of CHD has been paid much attention.In recent years,animal models have played a key role in the study of cardiovascular diseases.The cardiovascular system of pigs is similar to that of humans in terms of anatomical structure and pathophysiological mechanism,so the model pig has been widely recognized as an excellent model in the study of atherosclerosis.By referring to the diagnostic indicators and risk factors of human CHD,this manuscript aims to explore the evaluation criteria and construction methods of pigs with CHD model similar to human,so as to provide a good experimental model for pathogenesis and clinical application studies related to CHD.This review will lay the foundation for the development of new diagnosis and treatment methods for CHD.

coronary heart diseasemodel pigcardiovascular disease

骆庆龙、袁昭顺、张致远、廖晓波、印遇龙、刘梅

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湖南农业大学动物科学技术学院,长沙 410128

中南大学湘雅二医院,长沙 410011

中国科学院亚热带生态农业研究所,长沙 410125

冠状动脉粥样硬化性心脏病 模式猪 心血管疾病

2024

畜牧兽医学报
中国畜牧兽医学会

畜牧兽医学报

CSTPCD北大核心
影响因子:0.729
ISSN:0366-6964
年,卷(期):2024.55(12)