畜牧兽医学报2024,Vol.55Issue(12) :5368-5378.DOI:10.11843/j.issn.0366-6964.2024.12.004

氧化应激对母畜子宫及妊娠影响的研究进展

Research Progress in the Effect of Oxidative Stress on Uterus and Pregnancy in Female Livestock

孟亚轩 刘彦 韦兴茹 陈国顺 冯涛
畜牧兽医学报2024,Vol.55Issue(12) :5368-5378.DOI:10.11843/j.issn.0366-6964.2024.12.004

氧化应激对母畜子宫及妊娠影响的研究进展

Research Progress in the Effect of Oxidative Stress on Uterus and Pregnancy in Female Livestock

孟亚轩 1刘彦 2韦兴茹 3陈国顺 4冯涛1
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作者信息

  • 1. 甘肃农业大学动物科学技术学院,兰州 730070;北京市农林科学院畜牧兽医研究所,北京 100097;北京市农林科学院-美国俄克拉荷马州立大学动物科学联合实验室,北京 100097
  • 2. 北京市农林科学院畜牧兽医研究所,北京 100097;北京市农林科学院-美国俄克拉荷马州立大学动物科学联合实验室,北京 100097
  • 3. 北京市饲料工业协会,北京 100107
  • 4. 甘肃农业大学动物科学技术学院,兰州 730070
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摘要

氧化应激是细胞内外环境变化导致产生过多活性氧的状态,在调控子宫功能中发挥着重要作用.近年来,研究表明氧化应激可以通过影响子宫内生殖激素、免疫反应、调节子宫环境和细胞信号传导等途径调控母畜子宫功能.此外,过度氧化应激会损害母体和胎盘功能,与子宫内膜癌、先兆子痫、妊娠期糖尿病和宫内生长受限等生殖疾病的形成关系密切.本文综述了近年来关于氧化应激调控母畜子宫功能的研究进展,旨在深入了解氧化应激对母畜子宫功能的影响,为提高母畜繁殖效率提供理论指导和实践应用.

Abstract

Oxidative stress is a state of excessive reactive oxygen species produced by changes of intracellular and extracellular environment,which plays an important role in the regulation of uterine function.In recent years,studies have shown that oxidative stress can regulate the func-tion of the uterus by affecting reproductive hormones,immune responses,regulating uterine en-vironment and cell signaling.In addition,excessive oxidative stress can impair maternal and pla-cental function,closely related to reproductive diseases such as endometrial carcinoma,pre-ec-lampsia,gestational diabetes mellitus,and intrauterine growth retardation.This paper reviewed the research progress on the regulation of oxidative stress on the uterine function of female live-stock in recent years,in order to better understanding the effect of oxidative stress on the uterine function of female animals,providing new theoretical guidance and practical application for im-proving the reproduction efficiency of female livestock.

关键词

氧化应激/母畜/子宫/激素/炎症/生殖疾病

Key words

oxidative stress/female livestock/uterus/hormone/inflammation/reproductive dis-ease

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出版年

2024
畜牧兽医学报
中国畜牧兽医学会

畜牧兽医学报

CSTPCD北大核心
影响因子:0.729
ISSN:0366-6964
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