Progress on Application of Animal Intestinal Organoids
Multiple methods for culturing intestinal organoids from domestic animals and compan-ion animals have been established recently.Intestinal organoids exemplify the structures and functions of intestinal epithelium,being an in vitro model somewhere in between stable cell lines and animal models.Currently,animal intestinal organoids can be applied to research on the path-ogenesis and treatment of intestinal diseases,as well as to explore host-pathogen interactions.In the study of enteral nutrition and enteral immunology,intestinal organoids can be used to im-prove feed utilization,screen suitable additives,and promote animal performance.In addition,animal intestinal organoids have great potential in the field of human translational medicine and regenerative medicine.In this paper,the main applications of animal intestinal organoids in the past five years were reviewed,and the future research directions were prospected.
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