Structures,Functions and Detection Methods of A1 and A2 β-casein in Milk
Casein is the main protein in milk,and β-casein is one of the casein proteins.A1 β-case-in and A2 β-casein are two different genotypes of β-casein.Due to the difference in the position 67 of the amino acid sequence,the structure of the two proteins are different,which leads to the difference in physiological functions that are related to human health.This article introduces the differences between the structure of A1 and A2 β-casein in milk,as well as the differences in mi-celle assembly,chaperone activity and product gel.Simultaneously,some of the links between A1 and A2 β-casein in milk and human health are reviewed,mainly reflected in gastrointestinal symptoms,type I diabetes,cardiovascular diseases and mental diseases.In addition,the existing detection methods of A1 β-casein and A2 β-casein in milk were summarized to strengthen the un-derstanding of A1 β-casein and A2 β-casein in milk and provide theoretical basis for the subse-quent study of other manifestations in nutrition.