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Integrins and their potential roles in mammalian pregnancy
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Integrins are a highly complex family of receptors that,when expressed on the surface of cells,can mediate recipro-cal cell-to-cell and cell-to-extracellular matrix(ECM)interactions leading to assembly of integrin adhesion complexes(IACs)that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion,migration,proliferation,survival,differentiation,and metabolism.All metazoan organisms possess integrins,and it is generally agreed that integrins were associated with the evolution of multicel-lularity,being essential for the association of cells with their neighbors and surroundings,during embryonic develop-ment and many aspects of cellular and molecular biology.Integrins have important roles in many aspects of embry-onic development,normal physiology,and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine,including mammalian pregnancy,in par-ticular implantation of the blastocyst to the uterine wall,subsequent placentation and conceptus(embryo/fetus and associated placental membranes)development.This review provides a succinct overview of integrin structure,ligand binding,and signaling followed with a concise overview of embryonic development,implantation,and early placentation in pigs,sheep,humans,and mice as an example for rodents.A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE)and conceptus trophoblast is then presented,followed by sequential summaries of integrin expression and function during gestation in pigs,sheep,humans,and rodents.As appropriate for this journal,summaries of integrin expression and function during gestation in pigs and sheep are in depth,whereas summaries for humans and rodents are brief.Because similar models to those illustrated in Fig.1,2,3,4,5 and 6 are present throughout the scientific literature,the illustrations in this manuscript are drafted as Viking imagery for entertainment purposes.
Department of Veterinary Integrative Biosciences,School of Veterinary Medicine and Biomedical Sciences,Texas A&M University,College Station,TX 77843-4459,USA
Department of Animal Science,College of Agriculture and Life Sciences,Texas A&M University,College Station,TX 77843-2471,USA
USDA-NRICGPRCB,NRSA DHHS/NIHUSDA-NRIUSDA National Institute of Food and Agriculture Research Initiative Competitive FellowshipAgriculture and Food Research Initiative CompetitiveUSDA National Institute of Food and AgricultureNational Institutes of Health
Gregory A.Johnson,Robert C.Burghardt,Fuller W.Bazer,et al.Integrins and their potential roles in mammalian pregnancy[J].畜牧与生物技术杂志(英文版),2024,15(1):1-19.DOI:10.1186/s40104-023-00918-0.
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