首页|Composition,function,and timing:exploring the early-life gut microbiota in piglets for probiotic interventions
Composition,function,and timing:exploring the early-life gut microbiota in piglets for probiotic interventions
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国家科技期刊平台
NETL
NSTL
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Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colo-nization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompa-nied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets'weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduc-tion of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forth-coming probiotic interventions.
Colonization resistanceIntestinal microbiotaPigletWeaningWeight gain
College of Animal Science and National Engineering Research Center for Breeding Swine Industry,South China Agricultural University,Guangzhou,Guangdong,People's Republic of China
Guangdong Provincial Key Labora-tory of Agro-Animal Genomics and Molecular Breeding,South China Agricul-tural University,Guangzhou,Guangdong,China
Yunfu Subcenter of Guang-dong Laboratory for Lingnan Modern Agriculture,Yunfu,Guangdong,China
National Engineering Research Center for Breeding Swine Industry,Wens Foodstuff Group Co.,Ltd
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Key Technologies Research and Development Program of Guangdong Province projectChina Postdoctoral science FoundationLocal Innovative and Research Teams Project of Guangdong ProvinceProject of Swine Innovation Team in the Guangdong Modern Agricultural Research System
国家科技期刊平台
NSTL
万方数据
