首页|Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic E.coli

Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic E.coli

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  • 国家科技期刊平台
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Background Our previous study has reported that supplementation of oligosaccharide-based polymer enhances gut health and disease resistance of pigs infected with enterotoxigenic E.coli(ETEC)F18 in a manner similar to car-badox.The objective of this study was to investigate the impacts of oligosaccharide-based polymer or antibiotic on the host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC F18.Results Multivariate analysis highlighted the differences in the metabolic profiles of serum and colon digesta which were predominantly found between pigs supplemented with oligosaccharide-based polymer and antibiotic.The rela-tive abundance of metabolic markers of immune responses and nutrient metabolisms,such as amino acids and car-bohydrates,were significantly differentiated between the oligosaccharide-based polymer and antibiotic groups(q＜0.2 and fold change＞2.0).In addition,pigs in antibiotic had a reduced(P＜0.05)relative abundance of Lachno-spiraceae and Lactobacillaceae,whereas had greater(P＜0.05)Clostridiaceae and Streptococcaceae in the colon digesta on d 11 post-inoculation(PI)compared with d 5 PI.Conclusions The impact of oligosaccharide-based polymer on the metabolic and microbial profiles of pigs is not fully understood,and further exploration is needed.However,current research suggest that various mecha-nisms are involved in the enhanced disease resistance and performance in ETEC-challenged pigs by supplementing this polymer.

CarbadoxColon microbiotaEnterotoxigenic E.coli F18MetabolomicsOligosaccharide-based polymerWeaned pigs

Kwangwook Kim、Cynthia Jinno、Xunde Li、David Bravo、Eric Cox、Peng Ji、Yanhong Liu

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Department of Animal Science,University of California,Davis,CA 95616,USA

Department of Animal Science,Michigan State University,East Lansing,MI 48824,USA

Cedars-Sinai Medical Center,Los Angeles,CA 90084,USA

School of Veterinary Medicine,University of California,Davis,CA 95616,USA

Pancosma|ADM,1180 Rolle,Switzerland

Nutreco Exploration,Nutreco,The Netherlands

Department of Virology,Parasitology and Immunology,Ghent University,9000 Ghent,Belgium

Department of Nutrition,University of California,Davis,CA 95616,USA

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Pancosma SA,Geneva,Switzerland,Jastro& Shields Graduate Research AwardUnited States Department of Agriculture(USDA)National Institute of Food and Agriculture(NIFA)multistate projectsmultistate projects

W4002NC1202

2024

10.1186/s40104-023-00956-8

畜牧与生物技术杂志(英文版)
中国科学技术协会

畜牧与生物技术杂志(英文版)

CSTPCD
影响因子：0.765
ISSN：1674-9782
年,卷(期)：2024.15(2)
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