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Role of immunomodulatory probiotics in alleviating bacterial diarrhea in piglets:a systematic review

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Role of immunomodulatory probiotics in alleviating bacterial diarrhea in piglets:a systematic review
Diarrhea is a common enteric disease in piglets that leads to high mortality and economic losses in swine produc-tion worldwide.Antibiotics are commonly used to prevent or treat diarrhea in piglets.However,irrational antibiotic use contributes to the development of resistance in bacteria and antibiotic residues in animal products,threatening public health,while causing gut microbiota dysbiosis and antibiotic-resistant bacterial infection in piglets.Therefore,the quest for alternative products(such as probiotics,prebiotics,organic acids,enzymes,essential oils,medium-chain fatty acids,zinc,and plant extracts)has recently been clearly emphasized through the increase in regulations regard-ing antibiotic use in livestock production.These antibiotic alternatives could lower the risk of antibiotic-resistant bacteria and meet consumer demand for antibiotic-free food.Several antibiotic alternatives have been proposed,including immunomodulatory probiotics,as candidates to reduce the need for antimicrobial therapy.Many studies have revealed that probiotics can avert and cure bacterial diarrhea by regulating the gut function and immune sys-tem of piglets.In this review,we focus on the major pathogenic bacteria causing piglet diarrhea,the research status of using probiotics to prevent and treat diarrhea,their possible mechanisms,and the safety issues related to the use of probiotics.Supplementation with probiotics is a possible alternative to antibiotics for the prevention or treatment of bacterial diarrhea in piglets.Furthermore,probiotics exert beneficial effects on feed efficiency and growth perfor-mance of piglets.Therefore,appropriate selection and strategies for the use of probiotics may have a positive effect on growth performance and also reduce diarrhea in piglets.This review provides useful information on probiotics for researchers,pig nutritionists,and the additive industry to support their use against bacterial diarrhea in piglets.

ClostridiumDiarrheaE.coliImmunomodulatory effectPigletsProbiotics

Sudeb Saha、Fu Namai、Keita Nishiyama、Julio Villena、Haruki Kitazawa

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Food and Feed Immunology Group,Laboratory of Animal Food Function,Graduate School of Agricultural Science,Tohoku University,Sendai 980-8572,Japan

Department of Dairy Science,Faculty of Veterinary,Animal and Bio-medical Sciences,Sylhet Agricultural University,Sylhet 3100,Bangladesh

Livestock Immunology Unit,International Education and Research Center for Food and Agricultural Immunology(CFAI),Tohoku University,Sen-dai 980-8572,Japan

Laboratory of Immunobiotechnology,Reference Centre for Lactobacilli(CERELA-CONICET),4000 Tucuman,CP,Argentina

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Clostridium Diarrhea E.coli Immunomodulatory effect Piglets Probiotics

2024

10.1186/s40104-024-01070-z

畜牧与生物技术杂志(英文版)
中国科学技术协会

畜牧与生物技术杂志(英文版)

CSTPCD
影响因子：0.765
ISSN：1674-9782
年,卷(期)：2024.15(6)