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Advances in single-cell transcriptomics in animal research
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国家科技期刊平台
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Advances in single-cell transcriptomics in animal research
Understanding biological mechanisms is fundamental for improving animal production and health to meet the grow-ing demand for high-quality protein.As an emerging biotechnology,single-cell transcriptomics has been gradually applied in diverse aspects of animal research,offering an effective method to study the gene expression of high-throughput single cells of different tissues/organs in animals.In an unprecedented manner,researchers have identi-fied cell types/subtypes and their marker genes,inferred cellular fate trajectories,and revealed cell-cell interactions in animals using single-cell transcriptomics.In this paper,we introduce the development of single-cell technology and review the processes,advancements,and applications of single-cell transcriptomics in animal research.We sum-marize recent efforts using single-cell transcriptomics to obtain a more profound understanding of animal nutrition and health,reproductive performance,genetics,and disease models in different livestock species.Moreover,the prac-tical experience accumulated based on a large number of cases is highlighted to provide a reference for determin-ing key factors(e.g.,sample size,cell clustering,and cell type annotation)in single-cell transcriptomics analysis.We also discuss the limitations and outlook of single-cell transcriptomics in the current stage.This paper describes the comprehensive progress of single-cell transcriptomics in animal research,offering novel insights and sustainable advancements in agricultural productivity and animal health.
Yunan Yan、Senlin Zhu、Minghui Jia、Xinyi Chen、Wenlingli Qi、Fengfei Gu、Teresa G.Valencak、Jian-Xin Liu、Hui-Zeng Sun
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Institute of Dairy Science,Ministry of Education Key Laboratory of Molecular Animal Nutrition,College of Animal Sciences,Zhejiang University,Hangzhou 310058,China
Key Laboratory of Dairy Cow Genetic Improvement and Milk Quality Research of Zhejiang Province,Zhejiang University,Hangzhou 310058,China
Agency for Health and Food Safety Austria,1220 Vienna,Austria
国家科技期刊平台
NSTL
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