首页|CAMKK2-AMPK axis endows dietary calcium and phosphorus levels with regulatory effects on lipid metabolism in weaned piglets
CAMKK2-AMPK axis endows dietary calcium and phosphorus levels with regulatory effects on lipid metabolism in weaned piglets
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国家科技期刊平台
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CAMKK2-AMPK axis endows dietary calcium and phosphorus levels with regulatory effects on lipid metabolism in weaned piglets
Background In the realm of swine production,optimizing body composition and reducing excessive fat accumula-tion is critical for enhancing both economic efficiency and meat quality.Despite the acknowledged impact of dietary calcium(Ca)and phosphorus(P)on lipid metabolism,the precise mechanisms behind their synergistic effects on fat metabolism remain elusive.Results Research observations have shown a decreasing trend in the percentage of crude fat in carcasses with increased calcium and phosphorus content in feed.Concurrently,serum glucose concentrations significantly decreased,though differences in other lipid metabolism-related indicators were not significant across groups.Under conditions of low calcium and phosphorus,there is a significant suppression in the expression of FABPs,CD36 and PPARy in the jejunum and ileum,leading to inhibited intestinal lipid absorption.Concurrently,this results in a marked increase in lipid accumulation in the liver.Conversely,higher levels of dietary calcium and phosphorus promoted intestinal lipid absorption and reduced liver lipid accumulation,with these changes being facilitated through the activation of the CAMKK2/AMPK signaling pathway by high-calcium-phosphorus diets.Additionally,the levels of calcium and phosphorus in the diet significantly altered the composition of liver lipids and the gut micro-biota,increasing α-diversity and affecting the abundance of specific bacterial families related to lipid metabolism.Conclusion The evidence we provide indicates that the levels of calcium and phosphorus in the diet alter body fat content and lipid metabolism by modulating the response of the gut-liver axis to lipids.These effects are closely asso-ciated with the activation of the CAMKK2/AMPK signaling pathway.
AMPKCAMKK2Dietary calcium and phosphorusIntestine-liver axisLipid metabolism
Zhenyan Miao、Yanjie Sun、Zhangjian Feng、Qiwen Wu、Xuefen Yang、Li Wang、Zongyong Jiang、Ying Li、Hongbo Yi
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State Key Laboratory of Swine and Poultry Breeding Industry,Key Laboratory of Animal Nutrition and Feed Science in South China,Ministry of Agriculture and Rural Affairs,Maoming Branch,Guangdong Laboratory for Lingnan Modern Agriculture,Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510642,China
College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China
AMPK CAMKK2 Dietary calcium and phosphorus Intestine-liver axis Lipid metabolism
国家科技期刊平台
NSTL
万方数据
