首页|Prebiotic galactooligosaccharide improves piglet growth performance and intestinal health associated with alterations of the hindgut microbiota during the peri-weaning period

Prebiotic galactooligosaccharide improves piglet growth performance and intestinal health associated with alterations of the hindgut microbiota during the peri-weaning period

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Prebiotic galactooligosaccharide improves piglet growth performance and intestinal health associated with alterations of the hindgut microbiota during the peri-weaning period
Background Weaning stress reduces growth performance and health of young pigs due in part to an abrupt change in diets from highly digestible milk to fibrous plant-based feedstuffs.This study investigated whether dietary galactoo-ligosaccharide(GOS),supplemented both pre-and post-weaning,could improve growth performance and intestinal health via alterations in the hindgut microbial community.Methods Using a 3×2 factorial design,during farrowing 288 piglets from 24 litters received either no creep feed(FC),creep without GOS(FG-)or creep with 5％GOS(FG+)followed by a phase 1 nursery diet without(NG-)or with 3.8％GOS(NG+).Pigs were sampled pre-(D22)and post-weaning(D31)to assess intestinal measures.Results Creep fed pigs grew 19％faster than controls(P＜0.01)prior to weaning,and by the end of the nursery phase(D58),pigs fed GOS pre-farrowing(FG+)were 1.85 kg heavier than controls(P＜0.05).Furthermore,pigs fed GOS in phase 1 of the nursery grew 34％faster(P＜0.04),with greater feed intake and efficiency.Cecal microbial com-munities clustered distinctly in pre-vs.post-weaned pigs,based on principal coordinate analysis(P＜0.01).No effects of GOS were detected pre-weaning,but gruel creep feeding increased Chao1 α-diversity and altered several genera in the cecal microbiota(P＜0.05).Post-weaning,GOS supplementation increased some genera such as Fusicateni-bacterand Collinsella,whereas others decreased such as Campylobacter and Frisingicoccus(P＜0.05).Changes were accompanied by higher molar proportions of butyrate in the cecum of GOS-fed pigs(P＜0.05).Conclusions Gruel creep feeding effectively improves suckling pig growth regardless of GOS treatment.When sup-plemented post-weaning,prebiotic GOS improves piglet growth performance associated with changes in hindgut microbial composition.

GalactooligosaccharideGut microbiomeIntestinal villiPrebioticsWeaning

Timothy E.Boston、Feng Wang、Xi Lin、Sung Woo Kim、Vivek Fellner、MarkF.Scott、Amanda L.Ziegler、Laurianne Van Landeghem、Anthony T.Blikslager、Jack Odle

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Department of Animal Science,College of Ag and Life Sciences,North Carolina State University,Raleigh,NC 27695,USA

Milk Specialties Global,Eden Prairie,MN 55344,USA

Department of Clinical Sciences,North Carolina State University,Raleigh,NC 27695,USA

Depart-ment of Molecular Biomedical Sciences,College of Veterinary Medicine,North Carolina State University,Raleigh,NC 27695,USA

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Galactooligosaccharide Gut microbiome Intestinal villi Prebiotics Weaning

2024

10.1186/s40104-024-01047-y

畜牧与生物技术杂志(英文版)
中国科学技术协会

畜牧与生物技术杂志(英文版)

CSTPCD
影响因子：0.765
ISSN：1674-9782
年,卷(期)：2024.15(6)