The role of heart sound spectrograms in monitoring left ventricular function in patients with mitral regurgitation
Objective To investigate the role of heart sound spectrograms obtained through wearable devices in monitoring left ventricular function in patients with different degrees of mitral regurgitation(MR).Methods A total of 102 MR patients admitted to Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,from June 2020 to May 2021 due to cardiovascular diseases were included.Patients were categorized into mild MR(72 cases)and moderate-to-severe MR groups(30 cases)based on whether the mitral regurgitation flow area/left atrial area ratio exceeded 20%.Duration of heart sound,maximum heart sound intensity,and maximum heart sound amplitude were analyzed based on heart sound spectrogram,and correlation analysis was conducted with left ventricular ejection fraction(LVEF)measured by echocardiography.Results The ratio of duration of the first heart sound to systolic duration(S11-S12/S11-S21)in heart sound spectrograms showed a linear correlation with LVEF(r=-0.535,P<0.01).The area under the curve(AUC)for using S11-S12/S11-S21 to determine reduced LVEF(LVEF<50%)was 0.840(95%CI=0.756-0.924,P<0.01),with a threshold of 55.50%,sensitivity of 78.6%,and specificity of 83.3%.Conclusion Heart sound spectrograms suggest a negative correlation between the proportion of the first heart sound duration during cardiac systolic period and LVEF in MR patients.There is potential value in utilizing heart sound spectrograms for at-home monitoring of cardiac function in patients with mitral valve diseases.
万方数据
维普
