Stroke is an acute cerebrovascular disease with characteristics of high morbidity,high mortality and high disability rate.The brain-gut axis plays a crucial role in regulating intestinal flora in stroke;the intestinal flora participates in the development and prognosis of stroke through blood pressure regulation,immune regulation,inflammatory response and nerve regulation.At the same time,microecological preparations and fecal microbiota transplantation provide new ideas and methods for the prevention and treatment of stroke.In recent years,the relationship between intestinal flora and stroke has attracted much attention.This article provides an overview of research progress of intestinal flora in the occurrence,development and treatment of stroke.