Relationship between serum levels of kallikrein 1,sex-determining region of Y-related high-mobility-group box 6,and prognosis after percutaneous coronary intervention in patients with acute coronary syndrome
Objective To investigate the relationship between kallikrein 1(KLK1),sex-determining region of Y-related high-mobility-group box 6(SOX6),and the prognosis after percutaneous coronary intervention(PCI)in patients with acute coronary syndrome(ACS).Methods A total of 122 ACS patients admitted to the Affiliated Hospital of Hebei University from January 2019 to November 2020 were selected as the research subjects.Based on the occurrence of major adverse cardiovascular events(MACE)within 1 year,patients were divided into a good prognosis group(96 cases)and a poor prognosis group(26 cases).Serum levels of KLK1 and SOX6 were detected by enzyme-linked immunosorbent assay.Receiver operating characteristic(ROC)curve was applied to evaluate the predictive value of KLK1 and SOX6 for MACE after PCI.Kaplan-Meier analysis was introduced to compare the prognosis of ACS patients with different KLK1 and SOX6 levels.Cox multivariate regression was performed to analyze the prognostic factors in patients with ACS.Results The serum hypersensitive C-reactive protein(hs-CRP)level in the poor prognosis group was higher than that in the good prognosis group(t=13.311,P<0.05),and the serum KLK1 and SOX6 levels were significantly lower than those in the good prognosis group(t=5.855,6.205;P<0.05).The number of implanted stents in the good prognosis group was lower than that in the poor prognosis group(t=2.369,P<0.05).The ROC curve showed that the AUCs of KLK1 and SOX6 for predicting prognosis were 0.798 and 0.760,respectively.Their combined AUC was 0.909,which was greatly higher than those of single predictions(Z=2.925,3.639;P<0.01),with sensitivity and specificity of 90.62%and 76.92%,respectively.Kaplan-Meier analysis showed that the incidence of MACE in ACS patients with low KLK1 expression was higher than that in patients with high KLK1 expression(Log rank χ2=8.674,P<0.01),and the same trend was observed for SOX6(Log rank χ2=23.539,P<0.01).Cox regression analysis showed that both KLK1 and SOX6 were protective factors for MACE in ACS patients after PCI(HR=0.725,0.618;P<0.05).Conclusion The expression levels of KLK1 and SOX6 are decreased in the serum of ACS patients with poor prognosis after PCI.Their combination has certain predictive value for the occurrence of MACE,and can be clinically used for the early assessment of the occurrence of MACE in ACS patients after PCI.
Kallikrein 1Sex-determining region of Y-related high-mobility-group box 6Acute coronary syndromePercutaneous coronary interventionPrognosis
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