Correlation between left ventricular ejection fraction and fasting plasma glucose levels with major adverse cardiovascular and cerebrovascular events in patients with coronary artery disease after percutaneous coronary intervention
Objective To explore the correlation between left ventricular ejection fraction(LVEF)and fasting plasma glucose(FPG)levels with the occurrence of major adverse cardiovascular and cerebrovascular events(MACCE)in patients with coronary artery disease(CAD)after percutaneous coronary intervention(PCI).Methods Data were extracted from the Dryad database of single-center retrospective study conducted at the Heart Institute,Faculdade de Medicina da Universidade de São Paulo,Brazil.A total of 573 CAD patients underwent PCI were included in this study.Based on the occurrence of MACCE during the follow-up period of 5 years,patients were divided into the MACCE group(164 cases)and the control group(409 cases).Clinical data including age,gender,LVEF,and FPG levels were compared between the two groups.Multivariate Cox regression analysis was used to evaluate the predictive value of LVEF and FPG levels in the occurrence of MACCE after PCI in patients with CAD.Kaplan-Meier method was used to evaluate survival differences among patients with different LVEF and FPG levels.Results LVEF of 50%-70%and LVEF>70%were protective factors for MACCE occurrence after PCI in CAD patients[HR(95%CI)=0.578(0.367-0.914),0.493(0.279-0.858);P<0.05].FPG≥6.1 mmol/L was a risk factor for the occurrence of MACCE after PCI in patients with CAD[HR(95%CI)=1.492(1.026-2.138),P<0.05].The survival rate of patients with LVEF<50%was lower than that of patients with LVEF of 50%-70%and LVEF>70%(χ2=5.530,7.450;P<0.05).The survival rate of patients with FPG<6.1 mmol/L was higher than that of patients with FPG≥6.1mmol/L(χ2=12.212,P<0.05).Conclusion LVEF and FPG levels are influencing factors for the occurrence of MACCE in CAD patients after PCI.
Left ventricular ejection fractionFasting plasma glucoseCoronary artery diseasePercutaneous coronary interventionMajor adverse cardiovascular and cerebrovascular events
万方数据
维普
