Analysis of serum levels of C1q tumor necrosis factor-related protein 1 and Krüppel-like transcription factor 2 in acute cerebral infarction patients and their correlation with carotid atherosclerotic plaque stability
Objective To investigate the serum levels of C1q tumor necrosis factor-related protein 1(CTRP1)and Krüppel-like transcription factor 2(KLF2)in patients with acute cerebral infarction(ACI)and their correlation with the stability of carotid atherosclerosis(CAS)plaque.Methods A total of 128 ACI patients treated at the Branch Hospital of Infectious Disease Hospital of Heilongjiang Province from June 2021 to January 2023 were collected as the ACI group.Based on the stability of CAS plaques in ACI patients,they were separated into the non plaque group(19 cases),the stable plaque group(45 cases),and the unstable plaque group(64 cases).Additionally,128 healthy individuals undergoing physical examinations during the same period were selected as the control group.The serum levels of CTRP1 and KLF2 were compared among the groups.Spearman method was applied to analyze the correlation between serum levels of CTRP1 and KLF2 in ACI patients and the stability of CAS plaques.Multivariate Logistic regression was applied to analyze the influencing factors affecting CAS plaque stability in ACI patients.Receiver operating characteristic curve was applied to analyze the predictive value of serum CTRP1 and KLF2 levels for CAS plaque instability in patients with ACI.Results Compared to the control group,the ACI group had higher serum CTRP1 levels and lower KLF2 levels(t=15.949,78.545;P<0.01).Serum levels of CTRP1,neutrophil count,low density lipoprotein cholesterol(LDL-C),and National Institutes of Health Stroke Scale(NIHSS)scores increased sequentially in the non plaque group,stable plaque group,and unstable plaque group(F=49.819,27.014,17.143,335.582;P<0.01),while KLF2 level decreased sequentially(F=127.385,P<0.01).There was a positive correlation between CTRP1 level and CAS plaque stability in ACI group(r=0.532,P<0.01),while KLF2 level was negatively correlated with CAS plaque stability(r=-0.614,P<0.01).Multivariate Logistic regression analysis showed that CTRP1,KLF2,LDL-C,neutrophil count,and NIHSS scores were influencing factors for the stability of CAS plaques in ACI patients[OR(95%CI)=3.154(1.533-6.488),0.763(0.648-0.898),2.373(1.328-4.239),2.148(1.278-3.611),2.723(1.355-5.471);P<0.01].The combined prediction of serum CTRP1 and KLF2 for CAS plaque instability in ACI patients had an area under curve of 0.897,with sensitivity of 90.62%and specificity of 75.56%,which was better than individual predictions(Z=2.585,2.237;P<0.05).Conclusion The serum level of CTRP1 is higher and the level of KLF2 is lower in ACI patients,both of which are correlated with CAS plaque stability.The combination of CTRP1 and KLF2 levels has a good predictive effect on CAS plaque instability in ACI patients.
万方数据
维普
