Predictive value of serum microRNA-199a-3p and zinc finger E-box-binding protein 1 expression levels for the prognosis of patients with acute coronary syndrome after percutaneous coronary intervention
Objective To explore the predictive value of microRNA-199a-3p(miR-199a-3p)and zinc finger E-box-binding protein 1(ZEB1)for the prognosis of patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods From May 2021 and May 2022,113 ACS patients admitted to Qinhuangdao Second Hospital for PCI surgery were selected as the observation group.Based on the occurrence of major adverse cardiovascular events(MACE)within one year after PCI,they were grouped into the MACE group(26 cases)and the non-MACE group(87 cases).Additionally,106 healthy individuals undergoing physical examinations during the same period were selected as the control group.Serum miR-199a-3p and ZEB1 levels were detected.Clinical data were compared between the MACE and non-MACE groups.Pearson correlation analysis was used to examine the relationship between serum miR-199a-3p and ZEB1 levels in patients.Multivariate Logistic regression was performed to analyze factors influencing the occurrence of MACE in ACS patients after PCI.ROC curve analysis was conducted to evaluate the predictive value of serum miR-199a-3p and ZEB1 for MACE in ACS patients after PCI.Results Compared to the control group,serum miR-199a-3p level in the observation group decreased,while ZEB1 level increased(t=13.709,25.641;P<0.05).There was a negative correlation between miR-199a-3p and ZEB1 in ACS patients(r=-0.421,P<0.05).The level of miR-199a-3p in ACS patients after PCI was higher than that before PCI,and the level of ZEB1 was lower(t=4.820,6.040;P<0.05).Significant differences were found between the MACE group and non-MACE group in terms of high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),left ventricular ejection fraction(LVEF),miR-199a-3p,and ZEB1 levels(t=3.310,2.717,3.947,7.068,6.544;P<0.05).LDL-C and ZEB1 levels were risk factors for MACE in ACS patients after PCI,while LVEF,HDL-C,and miR-199a-3p levels were protective factors.The area under the curve(AUC)for the combined prediction of MACE using serum miR-199a-3p and ZEB1 was 0.947,which was superior to the prediction using either marker alone(Z=1.970,2.791;P<0.05).Conclusion Serum levels of miR-199a-3p and ZEB1 in ACS patients are negatively correlated,and both have predictive value for MACE in ACS patients after PCI.The predictive value of combination of miR-199a-3p and ZEB1 is higher than that of either marker alone.
Acute coronary syndromeMicroRNA-199a-3pZinc finger E-box-binding protein 1Percutaneous coronary intervention
万方数据
维普
