Relationship between serum homocysteine,serum amyloid A,and S100β levels and carotid plaque stability in elderly patients with type 2 diabetes
Objective To explore the relationship between serum homocysteine(Hcy),serum amyloid A(SAA),and S100β levels and carotid plaque stability in elderly patients with type 2 diabetes.Methods A total of 186 elderly patients with type 2 diabetes admitted to People's Hospital of Deyang from June 2021 to June 2023 were selected as the case group,and 186 healthy individuals undergoing physical examinations during the same period served as the control group.Based on plaque status,patients in the case group were divided into an unstable plaque group(57 cases),a stable plaque group(32 cases),and a no-plaque group(97 cases).The serum Hcy,SAA,and S100β levels were retrospectively analyzed,along with clinical data from the unstable plaque group,stable plaque group,and no-plaque group.The correlation between serum Hcy,SAA,and S100β levels and carotid plaque stability in elderly patients with type 2 diabetes was analyzed using Spearman correlation analysis,and the influencing factors of carotid plaque stability in elderly patients with type 2 diabetes were analyzed using Logistic regression model.The receiver operating characteristic(ROC)curve was used to analyze the efficacy of serum Hcy,SAA,and S100β levels in evaluating unstable carotid plaques in elderly patients with type 2 diabetes.Results The serum levels of Hcy,SAA and S100β in the case group were higher than those in the control group(t=28.737,40.946,57.982;P＜0.05).There were significant differences in the duration of diabetes,fasting blood glucose,glycated hemoglobin,total cholesterol,low-density lipoprotein,Hcy,SAA,and S100β levels among the unstable plaque group,stable plaque group,and no-plaque group(P＜0.05).The serum levels of Hcy,SAA,and S100β in elderly patients with type 2 diabetes were positively correlated with the stability of carotid plaques(r=0.802,0.669,0.745;P＜0.01).The duration of diabetes,glycated hemoglobin,low-density lipoprotein,Hcy,SAA,and S100β were identified as risk factors for unstable carotid plaques in elderly patients with type 2 diabetes(OR=1.384,1.582,2.147,2.560,2.309,3.728;P＜0.05).Hcy,SAA,and S100β were all effective in assessing unstable carotid plaques in elderly patients with type 2 diabetes,with combined assessment outperforming individual assessments(Z=2.217,1.995,1.986;P＜0.05).Conclusion The serum levels of Hcy,SAA,and S100β are correlated with the stability of carotid plaques in elderly patients with type 2 diabetes,with combined assessment of these three factors outperforming individual assessments.
万方数据
维普
