Relationship between serum silent information regulatory protein 1,copeptin levels and long-term major adverse cardiovascular and cerebrovascular events in hemodialysis patients
Objective To investigate the relationship between serum levels of silent information regulatory protein 1(SIRT1),copeptin(CPP),and the occurrence of long-term major adverse cardiovascular and cerebrovascular events(MACCE)in hemodialysis patients.Methods A total of 146 hemodialysis patients admitted to Ya'an People's Hospital from June 1,2018 to June 1,2020 were selected as the observation group,and 140 healthy individuals undergoing physical examinations during the same period were selected as the control group.Based on the occurrence of MACCE over a 3-year follow-up,hemodialysis patients were grouped into a non-MACCE group with 76 cases and a MACCE group with 70 cases.Serum SIRT1 and CPP levels were measured using enzyme-linked immunosorbent assay(ELISA)and compared between groups.Clinical data were also compared between the non-MACCE group and MACCE group.Multivariate Cox regression analysis was used to identify factors influencing long-term MACCE in hemodialysis patients,and the predictive value of SIRT1 and CPP levels for long-term MACCE in hemodialysis patients was analyzed using receiver operating characteristic(ROC)curves.Results Compared with the control group,the hemodialysis patients had lower serum SIRT1 levels and higher CPP levels(t=21.783,17.893;P＜0.05).In the MACCE group,dialysis duration,total cholesterol,high-density lipoprotein cholesterol(HDL-C),uric acid,and CPP levels were higher than those in the non-MACCE group,while low-density lipoprotein cholesterol(LDL-C)and SIRT1 levels were lower(t=10.158,7.877,12.324,9.426,6.650,12.147,6.843;P＜0.05).Dialysis duration,HDL-C,uric acid,and CPP were identified as risk factors for long-term MACCE in hemodialysis patients,while SIRT1 was a protective factor(HR=2.916,3.274,3.247,3.716,0.759;P＜0.05).The area under the ROC curve(AUC)for predicting long-term MACCE in hemodialysis patients was 0.754 for SIRT1,0.849 for CPP,and 0.876 for the combined prediction.Conclusion Hemodialysis patients have lower serum SIRT1 level and higher CPP level,and both can predict long-term MACCE in these patients.
HemodialysisSilent information regulatory protein 1CopeptinMajor adverse cardiovascular and cerebrovascular events
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