Effects of resistance exercise on exercise tolerance and vascular endothelial regulatory factors in patients with coronary artery disease
Objective To investigate the effects of resistance exercise on exercise tolerance and vascular endothelial regulatory factors in patients with stable coronary artery disease(CHD).Methods A prospective cohort study was conducted,including 100 patients with stable CHD from October 2020 to October 2022 at the Second Affiliated Hospital of Baotou Medical College.Patients were randomly divided into a control group and a resistance exercise group,with a final study population of 77 patients,consisting of 36 in the control group and 41 in the resistance exercise group.The control group received standardized drug treatment,while the resistance exercise group performed low-intensity resistance exercise for 12 weeks according to an exercise prescription in addition to standardized drug treatment.The 6-minute walk distance was used to assess exercise tolerance,and ELISA was used to measure the levels of vascular endothelial growth factor(VEGF),nitric oxide(NO),and endothelin-1 in peripheral blood.The 6-minute walking distance,levels of VEGF,NO,and endothelin-1 were compared before and after 12 weeks of treatment in both groups.The incidence of serious cardiovascular adverse events was compared between the two groups after a 24-week follow-up.Results(1)Compared with before exercise,the 6-minute walking distance increased,while the resting systolic blood pressure and the resting diastolic blood pressure decreased in the resistance exercise group(t=7.538,2.290,2.639;P<0.05);VEGF and NO increased,while endothelin-1 decreased in the resistance exercise group(t=5.509,6.089,5.824;P<0.05).(2)Compared with the control group,the resistance exercise group had increased 6-minute walking distance,increased VEGF and NO levels,and decreased endothelin-1 level(t=3.504,3.559,3.502,3.645;P<0.05)after 12 weeks.(3)The difference in 6-minute walking distance before and after exercise in the resistance exercise group was positively correlated with the difference in VEGF and NO(r=0.385,0.485;P<0.05),and negatively correlated with the difference in endothelin-1(r=-0.510,P<0.01).(4)After a 24-week follow-up,there was no statistically significant difference in the incidence of serious cardiovascular adverse events between the two groups of CHD patients(8.33%vs.9.76%,P>0.05).Conclusion Low-intensity resistance exercise can increase the levels of VEGF and NO,decrease the level of endothelin-1,and improve the exercise tolerance of patients with stable CHD.
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