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儿童胰腺肿瘤手术方案探讨

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目的 探讨儿童胰腺肿瘤的手术治疗策略.方法 回顾性分析2003年至2020年于上海交通大学医学院附属新华医院及苏州大学附属儿童医院因胰腺肿瘤接受手术治疗的29例患儿临床和随访资料,其中男6例,女23例;年龄为(10.6±2.6)岁,范围在3~15岁.病理类型以实性假乳头状瘤最为常见(25例),其余为2例胰母细胞瘤,1例胰岛素瘤和1例炎性肌纤维母细胞瘤.所有患儿均根据肿瘤部位行胰腺部分切除术.结果 所有患儿均顺利完成手术,术后发生胆漏和出血各1例,经保守治疗逐渐好转,无术中术后死亡和发生胰瘘的患儿,手术并发症发生率为6.9%(2/29).29例患儿均获得随访,中位随访时间为50.8个月,随访时间生存率为100%,发生术后胰腺外分泌功能不足、内分泌功能不足及胆肠吻合口狭窄各1例,并发症发生率为10.3%(3/29).未发现胰腺内肿瘤复发,但3例出现术后新发的肝脏转移灶,复发率为10.3%(3/29).结论 胰腺部分切除术是治疗小儿胰腺肿瘤安全有效的方式,在胰十二指肠切除术中利用端端胰腺残端包埋术进行胰空肠吻合能有效降低术后胰瘘的发生率.儿童胰腺肿瘤整体预后良好,即使是出现术前转移或术后复发的患儿也可取得良好预后.
Approaches of pancreatic surgery for tumors in children
Objective To explore the tumor characteristics,surgical approaches and outcomes of pancreatic tumors in children.Methods From 2003 to 2020,demographic profiles,preoperative examinations,perioperative findings,short-term postoperative complications and long-term outcomes were retrospectively reviewed for 29 children aged under 18 years undergoing partial pancreatectomy for pancreatic tumors.There were 6 boys and 23 girls with an average age of 10.6(3-15)year.The most common histological tumors were solid pseudopapillary tumor(25/29)and pancreatoblastoma(2/29).Partial pancreatectomy was performed according to tumor locations.Results All surgical procedures were sucessful.Bile leakage(n=1)and hemorrhage(n=1)improved gradually after conservative treatment.There was no perioperative death or pancreatic fistula.The overall complication rate was 6.9%.During a median follow-up period of 50.8 month,survival rate was up to 100%.The complication rate was 10.3%.There were pancreatic exocrine insufficiency(n=1),endocrine insufficiency(n=1)and biliary-enteric anastomotic stenosis(n=1).No intrapancreatic tumor recurrence was noted.Three children developed postoperative liver metastases with a recurrent rate of 10.3%.Conclusions Partial pancreatectomy is both effective and safe for pancreatic tumors in children.End-to-end dunking pancreaticojejunostomy is recommended for preventing postoperative pancreatic fistula during pancreaticoduodenectomy and central pancreatectomy.The overall prognosis of pediatric pancreatic tumors is decent even in children with preoperative metastasis or recurrent pancreatic tumors.

Pancreatic neoplasmsPancreatic solid pseudopapillary neoplasmPrognosis

程橙、吕凡、黄顺根、沈涤华、王悍平、施佳、吴晔明

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上海交通大学医学院附属新华医院儿外科,上海 200092

苏州大学附属儿童医院外科,苏州 215003

胰腺肿瘤 胰腺实性假乳头状瘤 预后

2024

中华小儿外科杂志
中华医学会

中华小儿外科杂志

CSTPCD北大核心
影响因子:0.853
ISSN:0253-3006
年,卷(期):2024.45(1)
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