Research advances of matrix metalloproteinase-7 in the diagnosis and prognosis of neonatal biliary atresia
As a rare disease of infancy,biliary atresia(BA)is characterized by progressive inflammation and fibrination of intra/extra-hepatic bile ducts.The difficulty of early diagnosis of this disease results in an advanced age at Kasai surgery and a significantly higher rate of postoperative mortality and liver transplantation.Matrix metalloproteinase-7(MMP-7)is a matrix metalloproteinase capable of degrading extracellular matrix and other matrices.It is correlated closely with BA.In basic experiments,serum level of MMP-7 in BA children was significantly higher than that of non-BA subjects.This review focused upon the latest researches of MMP-7 in the diagnosis and prognosis of BA.
NETL
NSTL
万方数据
维普
