Research advances on regulatory mechanisms of intestinal microflora and intestinal neuroimmune network in constipated children
Constipation in children is composed of two types of organic and functional.The signal changes of abnormal intestinal flora may affect intestinal activities through the regulatory mechanisms of intestinal neuroimmune network,including mucosal barrier,immune response and enteric nervous system.Innate lymphoid cell(ILC)plays an important role in intestinal neuroimmune network.And ILC3 releases interleukin-22(IL-22)under the influence of intestinal flora signals,serving as a new target affecting the development of intestinal nervous system.The mechanism and signaling pathway related to ILC3 can provide new rationales for examining the signal communication between intestinal flora and host,improving intestinal function and relieving constipation symptoms.Here abnormal changes of intestinal microflora and intestinal neuroimmune network in constipated children and their regulatory mechanisms were reviewed.
NETL
NSTL
万方数据
维普
