Staphylococcus aureus is the most common pathogen cultured for musculoskeletal infection in children.However,in clinical practices,culture is often negative and no pathogen is detected.For culture-negative musculoskeletal infections,there is no indication for antibiotics because of an absence of pathogenic bacteria and drug sensitivity.This review focused upon the problems related to culture-negative musculoskeletal infection to provide references for clinicians in a proper management.
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